Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | glioma tissues, cell lines (U87, U251) |
| Expression Pattern | up-regulated |
| Function Description | Taken together, these findings suggest that H19 plays an important role in the development of TMZ resistance, and may represent a novel therapeutic target for TMZ-resistant gliomas. Importantly, expression of H19 variant 1 was significantly higher in TMZ-resistant tumor tissues than in TMZ-sensitive tumor tissues. |
| Pubmed ID | 27366087 |
| Year | 2016 |
| Title | Knockdown of long noncoding RNA H19 sensitizes human glioma cells to temozolomide therapy |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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