Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | bladder carcinoma tissues, cell lines (BIU, 5673, EJ, T24) |
| Expression Pattern | up-regulated |
| Function Description | up-regulating H19 antagonized miR-29b-3p-mediated proliferation, migration and EMT suppression in BC cells. Furthermore,H19 knockdown partially reversed the function of miR-29b-3p inhibitor on DNMT3B and facilitated miR-29b-3p-induced MET. Taken together, we demonstrated for the first time that H19 might function as ceRNA (competing endogenous RNA) for miR-29b-3p and relieve the suppression for DNMT3B, which led to EMT and metastasis of BC. Our findings highlight a novel mechanism of H19 in progression of BC and provide H19/miR-29b-3p/ DNMT3B axis as a promising therapeutic target for BC. |
| Pubmed ID | 28779971 |
| Year | 2017 |
| Title | lncRNA H19 regulates epithelialâ??mesench mal transition and metastasis of bladder cancer by miR-29b-3p as competing endogenous RNA |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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