In our study, we confirmed that the T variant of rs217727 was consistently associated with an increased risk of BC in the codominant model.Another previous study by Yang et al32 found that the rs217727 CT + TT genotypes were correlated with significantly increased gastric cancer risk (OR 1.32, 95% CI 1.01â??1.71), while in functional assay analysis, the rs217727 CT, TT, or CT + TT genotypes were found not to affect H19 mRNA expression levels compared with the CC genotype, suggesting the C/T mutation might potentially change translational efficiency and lead to a transformation in H19 structure, thereby influencing the function of H19.