Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay etc. |
| Sample | CRC tissues, cell lines (HCT116, SW480, 293TN) |
| Expression Pattern | up-regulated |
| Function Description | H19 expression was upregulated in CRC tissues compared with adjacent noncancerous tissues. H19 overexpression facilitated colon cancer cell proliferation, whereas H19 knockdown inhibited cell proliferation. miR-200a bound to H19 and inhibited its expression, thereby decreasing CRC cell proliferation. H19 promotes cell proliferation by competitively binding to miR-200a and derepressing B-catenin in CRC. |
| Pubmed ID | 28164117 |
| Year | 2017 |
| Title | The lncRNA H19 Promotes Cell Proliferation by Competitively Binding to miR-200a and Derepressing B-Catenin Expression in Colorectal Cancer. |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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