Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay etc. |
| Sample | gastric cancer tissues, cell lines (SGC7901, MKN45, MKN-28 etc.) |
| Expression Pattern | up-regulated |
| Function Description | The results showed that overexpression of H19 promoted the features of GC including proliferation, migration, invasion and metastasis. H19 and its associated miR-675 act as oncogenes by promoting cell growth and malignant transformation in human gastric cancer. The upregulation of H19 and miR-675 in GC suggests that both H19 and miR-675 are important factors in GC tumorigenesis and metastasis. Furthermore, we showed that H19 plays additional roles mediated by separate pathways and interaction with its target gene ISM1. |
| Pubmed ID | 24810858 |
| Year | 2014 |
| Title | Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer. |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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