Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | breast cancer tissues, cell lines (MCF-7, MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | Quantitation of H19 lncRNA in human breast cancer tissues showed that the level of H19 lncRNA was higher in ER-positive than in ER-negative tumor tissues. These results suggest that H19 is an estrogen-inducible gene and plays a key role in cell survival and in estrogen-induced cell proliferation in MCF-7 cells, H19 expression is ER-dependent and induced by estrogen through the traditional genomic pathway of estrogen-ER interaction with the gene. |
| Pubmed ID | 25846769 |
| Year | 2015 |
| Title | H19 lncRNA mediates 17B-estradiol-induced cell proliferation in MCF-7 breast cancer cells. |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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