Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot analysis ect. |
| Sample | HCC tumor tissues |
| Expression Pattern | up-regulated |
| Function Description | H19 as one of the most upregulated long noncoding RNA (lncRNA) in association with Tgfbr2 inactivation in TICs. Tgfbr2 inactivation by Ad-Cre led to a 5-fold increase of H19 expression in TICs. Accordingly, TGF-B treatment reduced H19 expression.low level of H19 mRNA expression in human HCC tissues from patients with the epithelial TGF-B gene signature in association with favorable prognosis. |
| Pubmed ID | 30014520 |
| Year | 2018 |
| Title | A novel TGF-β and H19 signaling axis in tumor-initiating hepatocytes that regulates hepatic carcinogenesis. |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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