Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✔ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | multiple myeloma |
| ICD-0-3 | C42.1 M9732/3 |
| Methods | qPCR, Western blot |
| Sample | bone marrow tissues, cell lines ( OPM-2, U266, KM3, XG1, JJN3, RPMI, U1996, H929, and MM1S) |
| Expression Pattern | up-regulated |
| Function Description | H19 knockdown induced by shRNA transfection significantly inhibited proliferation, viability and colony formation in MM cells, as well as inactivated NF-kB pathway.combination treatment of H19 knockdown and NF-kB suppression (induced by specific inhibitor PDTC) produced synergistically inhibitory effects.patients with high expression of H19 had a lower survival rate.H19 was involved in MM cell growth. The linkage between H19 and NF-kB pathway may provide a novel interpretation for the mechanism of H19's growth regulation in MM. |
| Pubmed ID | 29273733 |
| Year | 2017 |
| Title | Knockdown of long non-coding RNA H19 inhibits multiple myeloma cell growth via NF-kB pathway. |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for multiple myeloma | Omim Cosmic |
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