Detail
| LncRNA Name | HIF1A-AS2 |
| Synonyms | HIF1A-AS2, 3'aHIF-1A, aHIF |
| Region | GRCh38_14:61715558-61751097 Sequence |
| Ensembl | ENSG00000258667 |
| RefSeq | NR_045406 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioblastoma |
| ICD-0-3 | M9440/3 |
| Methods | RIP, RNA pull-down assay etc. |
| Sample | glioblastoma tissues, cell lines (G2, G6, G33, G34, G35, G44, G62, G88, G146, G157, G91) |
| Expression Pattern | up-regulated |
| Function Description | We identified hypoxia-inducible factor 1 alpha-antisense RNA 2 (HIF1A-AS2) as a subtype-specific hypoxia-inducible lncRNA, upregulated in mesenchymal GSCs. Its deregulation affects GSC growth, self-renewal, and hypoxia-dependent molecular reprogramming. Downregulation of HIF1A-AS2 led to delayed growth of mesenchymal GSC tumors, survival benefits, and impaired expression of HMGA1 in vivo. |
| Pubmed ID | 27264189 |
| Year | 2016 |
| Title | The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches. |
| External Links |
| Links for HIF1A-AS2 | GenBank HGNC lncrnadb Noncode |
| Links for glioblastoma | Omim Cosmic |
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