Detail
| LncRNA Name | HIF2PUT |
| Synonyms | EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 |
| Region | GRCh38_2:46293667-46386703 Sequence |
| Ensembl | ENSG00000116016 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR etc. |
| Sample | osteosarcoma tissues |
| Expression Pattern | up-regulated |
| Function Description | Compared with non-cancerous bone tissues, HIF-2a mRNA and HIF2PUT expression were both significantly upregulated in osteosarcoma tissues. Interestingly, the expression levels of HIF-2a mRNA in osteosarcoma tissues were positively correlated with those of HIF2PUT. Additionally, osteosarcoma patients with HIF-2a mRNA and/or HIF2PUT over-expression more frequently had large tumor size, advanced clinical stage and positive distant metastasis. Moreover, osteosarcoma patients with HIF-2a mRNA and/or HIF2PUT over-expression had a significantly shorter overall and disease-free survival. |
| Pubmed ID | 27623205 |
| Year | 2016 |
| Title | Combined over-expression of the hypoxia-inducible factor 2a gene and its long non-coding RNA predicts unfavorable prognosis of patients with osteosarcoma. |
| External Links |
| Links for HIF2PUT | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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