Detail
| LncRNA Name | HMMR-AS1 |
| Synonyms | NA |
| Region | GRCh38_5:163483065-163494058 Sequence |
| Ensembl | ENSG00000251018 |
| RefSeq | NR_109892 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioblastoma |
| ICD-0-3 | M9440/3 |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (U87, U251, A172, and U118) |
| Expression Pattern | up-regulated |
| Function Description | We identify that an HMMR antisense lncRNA, HMMR-AS1, is hyperexpressed in GBM cell lines and stabilizes HMMR mRNA. Knockdown of HMMR-AS1 reduces HMMR expression; inhibits cell migration, invasion, and mesenchymal phenotypes; and suppresses GBM cell growth both in vitro and in vivo. Moreover, knockdown of HMMR-AS1 radiosensitizes GBM by reducing DNA repair proteins ATM, RAD51, and BMI1. Our data demonstrate a mechanism of sense-antisense interference between HMMR and HMMR-AS1 in GBM and suggest that targeting HMMR-AS1 is a potential strategy for GBM treatment. |
| Pubmed ID | 29574252 |
| Year | 2018 |
| Title | Targeting Long Noncoding RNA HMMR-AS1 Suppresses and Radiosensitizes Glioblastoma. |
| External Links |
| Links for HMMR-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for glioblastoma | Omim Cosmic |
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