Detail
| LncRNA Name | HNF1A-AS1 |
| Synonyms | HNF1A-AS1, C12orf27, NCRNA00262, FLJ38690, HAS1 |
| Region | GRCh38_12:120941728-120980965 Sequence |
| Ensembl | ENSG00000241388 |
| RefSeq | NR_024345 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Luciferase reporter assay, RIP |
| Sample | colon cancer tissues, cell lines (SW480, CaCO2, RKO, HCT8, HCT116, SW620, FHC) |
| Expression Pattern | up-regulated |
| Function Description | HNF1A-AS1 was frequently upregulated in colon cancer tissues and associated with poor prognosis.Upregulated HNF1A-AS1 promoted colon cancer cell viability, migration and invasion both in vitro and in vivo.HNF1A-AS1 silencing impaired tumor growth and metastasis.HNF1A-AS1 functioned as an oncogene in metastasis of colon cancer in part through serving as a competing endogenous RNA to modulate miRNA-34a expression, subsequently with repression of miR-34a/SIRT1/p53 feedback loop and activation of canonical Wnt signaling pathway. |
| Pubmed ID | 28943452 |
| Year | 2017 |
| Title | Long non-coding RNA HNF1A-AS1 mediated repression of miR-34a/SIRT1/p53 feedback loop promotes the metastatic progression of colon cancer by functioning as a competing endogenous RNA. |
| External Links |
| Links for HNF1A-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for colon cancer | Omim Cosmic |
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