Detail
LncRNA Name | HNF1A-AS1 |
Synonyms | HNF1A-AS1, C12orf27, NCRNA00262, FLJ38690, HAS1 |
Region | GRCh38_12:120941728-120980965 Sequence |
Ensembl | ENSG00000241388 |
RefSeq | NR_024345 |
Circulating | ✘ |
Drug-resisitant | ✘ |
Prognostic | ✘ |
MiRNA | ✘ |
Variant | ✘ |
TF | ✘ |
Methylation | ✘ |
Cancer Name | colorectal cancer |
ICD-0-3 | C19.9 |
Methods | qPCR etc. |
Sample | cell lines (SW480, SW620, DLD1, HT29, HCT116, Ls174T, LOVO) |
Expression Pattern | up-regulated |
Function Description | The results demonstrated that HNF1A-AS1 was distinctly upregulated in CRC tissues and associated with CRC metastasis to the lymph nodes. Reverse transcription quantitative polymerase chain reaction revealed that HNF1A-AS1 was also upregulated in CRC cell lines and localized in the nucleus. In addition, knockdown of HNF1A-AS1 expression notably inhibited CRC cell proliferation, migration, invasion and colony formation, and suppressed Sphase entry in vitro. Taken together, these results suggested that HNF1A-AS1 might serve as a promising prognostic marker for CRC tumorigenesis and progression. |
Pubmed ID | 28791380 |
Year | 2017 |
Title | Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma |
External Links |
Links for HNF1A-AS1 | GenBank HGNC lncrnadb Noncode |
Links for colorectal cancer | Omim Cosmic |
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