Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name HNF1A-AS1
   Synonyms HNF1A-AS1, C12orf27, NCRNA00262, FLJ38690, HAS1
   Region GRCh38_12:120941728-120980965    Sequence
   Ensembl ENSG00000241388
   RefSeq NR_024345
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name colorectal cancer
   ICD-0-3 C19.9  
   Methods qPCR etc.
   Sample cell lines (SW480, SW620, DLD1, HT29, HCT116, Ls174T, LOVO)
   Expression Pattern up-regulated
   Function Description

The results demonstrated that HNF1A-AS1 was distinctly upregulated in CRC tissues and associated with CRC metastasis to the lymph nodes. Reverse transcription quantitative polymerase chain reaction revealed that HNF1A-AS1 was also upregulated in CRC cell lines and localized in the nucleus. In addition, knockdown of HNF1A-AS1 expression notably inhibited CRC cell proliferation, migration, invasion and colony formation, and suppressed Sphase entry in vitro. Taken together, these results suggested that HNF1A-AS1 might serve as a promising prognostic marker for CRC tumorigenesis and progression.

   Pubmed ID 28791380
   Year 2017
   Title Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma
   External Links
   Links for  HNF1A-AS1 GenBank       HGNC       lncrnadb       Noncode
   Links for  colorectal cancer Omim       Cosmic

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