Detail
| LncRNA Name | HNF1A-AS1 |
| Synonyms | HNF1A-AS1, C12orf27, NCRNA00262, FLJ38690, HAS1 |
| Region | GRCh38_12:120941728-120980965 Sequence |
| Ensembl | ENSG00000241388 |
| RefSeq | NR_024345 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 M8140/3 |
| Methods | qPCR, RNAi, Western blot, RIP etc. |
| Sample | lung adenocarcinoma tissues, cell lines (A549, SPC-A1, H1650) |
| Expression Pattern | up-regulated |
| Function Description | HNF1A-AS1 was significantly up-regulated in lung adenocarcinoma tissues compared with corresponding non-tumor tissues, and its expression level was significantly correlated with TNM stage, tumor size, and lymph node metastasis. Moreover, HNF1A-AS1 was determined to promote tumor proliferation and metastasis, both in vitro and in vivo, by regulating cyclin D1, E-cadherin, N-cadherin and B-catenin expression. In addition, the binding of HNF1A-AS1 to DNMT1 may explain its regulation of E-cadherin. |
| Pubmed ID | 25863539 |
| Year | 2015 |
| Title | The long non-coding RNA HNF1A-AS1 regulates proliferation and metastasis in lung adenocarcinoma. |
| External Links |
| Links for HNF1A-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for lung adenocarcinoma | Omim Cosmic |
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