Detail
| LncRNA Name | HNF1A-AS1 |
| Synonyms | HNF1A-AS1, C12orf27, NCRNA00262, FLJ38690, HAS1 |
| Region | GRCh38_12:120941728-120980965 Sequence |
| Ensembl | ENSG00000241388 |
| RefSeq | NR_024345 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | Microarray, RT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | human HCC cell lines (Huh-7, MHCC-97 L, MHCC-97H, MHCC-LM3, SMMC-7721 and YY-8103 ), |
| Expression Pattern | down-regulated |
| Function Description | HNF1a activated the transcription of HNF1A-AS1 by directly binding to its promoter region. HNF1A-AS1 inhibited the growth and the metastasis of HCC cells in vitro and in vivo. Moreover, knockdown of HNF1A-AS1 reversed the suppressive effects of HNF1a on the migration and invasion of HCC cells. Importantly, HNF1A-AS1 directly bound to the C-terminal of SHP-1 with a high binding affinity (KD=59.57±14.29nM) and increased the phosphatase activity of SHP-1. Inhibition of SHP-1 enzymatic activity substantially reversed the HNF1a- or HNF1A-AS1-induced reduction on the metastatic property of HCC cells. |
| Pubmed ID | 29466992 |
| Year | 2018 |
| Title | The HNF1a-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1. |
| External Links |
| Links for HNF1A-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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