Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cardia adenocarcinoma |
| ICD-0-3 | C16.0 M8140/3 |
| Methods | qPCR, RFLP-PCR etc. |
| Sample | blood |
| Expression Pattern | up-regulated |
| Function Description | Among three htSNPs of the HOTAIR gene (rs12826786 C>T, rs4759314 A>G, and rs10783618 C>T), only the T allele of rs12826786 was found to increase the risk of developing GCA and was associated with smoking habit and tumor-node-metastasis (TNM) stage. In addition, higher expression levels of HOTAIR were found in tumor tissues and rs12826786 SNP has a genotype-specific effetc on HOTAIR expression. A high HOTAIR expression level was associated with poor GCA patients' survival. |
| Pubmed ID | 25476857 |
| Year | 2014 |
| Title | Associations between polymorphisms of HOTAIR and risk of gastric cardia adenocarcinoma in a population of north China. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for gastric cardia adenocarcinoma | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.