Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | renal cancer |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | cell lines (86-O, ACHN) |
| Expression Pattern | up-regulated |
| Function Description | We found that HOTAIR expression is inversely correlated to miR-141 expression in renal carcinoma cells. HOTAIR promotes malignancy, including proliferation and invasion, whereas miR-141 suppresses malignancy in human cancer cells. miR-141 binds to HOTAIR in a sequence-specific manner and suppresses HOTAIR expression and functions, including proliferation and invasion. |
| Pubmed ID | 24616104 |
| Year | 2014 |
| Title | Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for renal cancer | Omim Cosmic |
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