Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qPCR, Western blot, Luciferase Reporter Assays |
| Sample | esophageal cancer tissues, cell lines (KYSE30, KYSE150, TE-1, Eca-1, Eca-109) |
| Expression Pattern | up-regulated |
| Function Description | High lncRNA-HOTAIR expression was associated with significantly poorer overall survival in EC. Mechanistic investigations revealed lncRNA-HOTAIR promotes the EMT by acting as a miR-148a sponge to positively regulate Snail2 expression |
| Pubmed ID | 28441714 |
| Year | 2017 |
| Title | Long non-coding RNA HOTAIR functions as miRNA sponge to promote the epithelial to mesenchymal transition in esophageal cancer |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for esophageal cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.