Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | melanoma |
| ICD-0-3 | M8720/3 |
| Methods | qPCR, ISH etc. |
| Sample | serum, melanoma tissues |
| Expression Pattern | up-regulated |
| Function Description | The staining of HOTAIR resulted very weak in the primary pT1 lesions, while it was very strong in all pairs of primary tissues and corresponding metastases. Surprisingly, we found the presence of HOTAIR in some intratumoral lymphocytes, while this positivity decreased in lymphocyte component further away from the tumor. HOTAIR was also detected in the serum of selected metastatic patients. |
| Pubmed ID | 28067428 |
| Year | 2017 |
| Title | HOTAIR role in melanoma progression and its identification in the blood of patients with advanced disease. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for melanoma | Omim Cosmic |
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