Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | urothelial cancer |
| ICD-0-3 | M8120/3 |
| Methods | microarray, qPCR, Western blot, ChIP etc. |
| Sample | urothelial cancer tissues, cell lines (VM-CUB1 and 5637) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR was overexpressed in approximately half of UC tissues and cell lines. Effects of HOTAIR overexpression differed between cell lines. Whereas VM-CUB1 cells acquired the expected phenotype with increased proliferation, clonogenicity, anchorage independent growth, migratory activity and epithelial-to-mesenchymal transition, 5637 cells grew more slowly displaying induction of senescence and related immune response genes. |
| Pubmed ID | 25994132 |
| Year | 2015 |
| Title | The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for urothelial cancer | Omim Cosmic |
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