Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✔ |
| Methylation | ✔ |
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (CCL228, HeLa, MCF7, SH-SY5Y) |
| Expression Pattern | up-regulated |
| Function Description | Along with HIF1a, histone methylases MLL1 and histone acetylase p300 are enriched at the HOTAIR promoter under hypoxia. The levels of H3K4-trimethylation and histone acetylation are also enriched at the HOTAIR promoter. Furthermore, knockdown of MLL1 downregulated the hypoxia-induced HOTAIR expression, indicating key roles of MLL1 in hypoxia-induced HOTAIR expression. HIFs are transcription factors and regulate the expression of a variety of target genes under hypoxia and that contribute to the tumor growth and metastasis.Misregulation and mutations in lncRNAs are widely associated with a variety of human diseases. |
| Pubmed ID | 28756022 |
| Year | 2017 |
| Title | Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for colon cancer | Omim Cosmic |
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