Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | head and neck squamous cell carcinoma |
| ICD-0-3 | C76.0 M8070/3 |
| Methods | qPCR, RNAi, Western blot, RIP, Luciferase reporter assay, Cell migration and invasion assay etc. |
| Sample | HNSC tissues, cell lines (SCC25, HN4, Cal27, SCC4, HN30, HN12, HN13 and FaDu) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of HOTAIR and HuR decreased cell viability, cellular migration and invasion. Moreover, HuR interacted and stabilized HOTAIR stability and thus promoted HOTAIR expression. Notably, HOTAIR acted as a miRNA sponge for HuR. HuR also reinforced HOTAIR sponge activity through miRNA recruitment, thus enhancing HuR expression in turn. Finally, HuR and HOTAIR levels were positively correlated and significantly up-regulated in tumours samples. |
| Pubmed ID | 27941336 |
| Year | 2016 |
| Title | A Feed-Forward Regulatory Loop between HuR and the Long Noncoding RNA HOTAIR Promotes Head and Neck Squamous Cell Carcinoma Progression and Metastasis. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for head and neck squamous cell carcinoma | Omim Cosmic |
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