Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 M8140/3 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay, MTT assay etc. |
| Sample | LAD tissues, cell line (A549/CDDP) |
| Expression Pattern | up-regulated |
| Function Description | Our results showed that HOTAIR was significantly upregulated in A549/CDDP cells compared with parental A549 cells. The results showed that si-HOTAIR increased miR-326 expression (Fig. 6b) and synergistically reduced SP1 expression (Fig. 6c), ultimately enhanced sensitivity to cisplatin in A549/CDDP cells. In contrast to si-HOTAIR, pcDNA/HOTAIR vector inhibited miR-326 expression and synergistically enhanced SP1 expression in A549 cells |
| Pubmed ID | 27460077 |
| Year | 2016 |
| Title | miR-326 reverses chemoresistance in human lung adenocarcinoma cells by targeting specificity protein 1. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for lung adenocarcinoma | Omim Cosmic |
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