Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 M8140/3 |
| Methods | qPCR, RNAi etc. |
| Sample | NSCLC tissues, cell lines (A549, PC9, H1299, H520, HBE) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR regulates the ratio of FOXA1 to FOXA2 and migration and invasion. HOTAIR and the ratio of FOXA1 to FOXA2 are negatively correlated. HOTAIR knockdown inhibits migration and invasion. HOTAIR is associated with LSH, and this association linked with the binding of LSH in the promoter of FOXA1, not FOXA2. Targeted inhibition of HOTAIR suppresses the migratory and invasive properties |
| Pubmed ID | 26658322 |
| Year | 2015 |
| Title | The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for lung adenocarcinoma | Omim Cosmic |
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