Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 M8070/3 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | OSCC tissues, cell lines (TSCCA, Tca8223 etc.) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we show that HOTAIR expression increased in oral squamous cell carcinoma (OSCC) compared with non-tumor tissue and is associated with metastasis, the stage and histological differentiation. Furthermore, significant negative correlation between HOTAIR levels and E-cadherin levels was found in OSCC tissues and cell lines, and HOTAIR contributed to the regulation of E cadherin through binding to EZH2 and H3K27me3 with the E-cadherin promoter. |
| Pubmed ID | 25901533 |
| Year | 2015 |
| Title | Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for oral squamous cell carcinoma | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.