Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 M8140/3 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | lung adenocarcinoma tissues, cell lines (A549/DDP, SPC-A1 etc.) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we show that HOTAIR expression was significantly upregulated in cisplatin-resistant A549/DDP cells compared with in parental A549 cells. Knockdown of HOTAIR by RNA interference could resensitize the responses of A549/DDP cells to cisplatin both in vitro and in vivo. In contrast, overexpression of HOTAIR could decrease the sensitivity of A549 and SPC-A1 cells to cisplatin. |
| Pubmed ID | 24155936 |
| Year | 2013 |
| Title | The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregualtion of p21(WAF1/CIP1) expression. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for lung adenocarcinoma | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.