Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Luciferase reporter assay etc. |
| Sample | cell lines (HCT116, SW480, LOVO, HT29, FHC) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR knockdown promoted apoptosis and inhibited cell proliferation, migration and invasion in vitro and in vivo.Moreover, HOTAIR modulated the progression of colorectal cancer by competitively binding miR-197.Taken together, our study has identified a novel pathway through which HOTAIR exerts its oncogenic role,and provided a molecular basis for potential applications of HOTAIR in the prognosis and treatment of colorectal cancer. |
| Pubmed ID | 29137688 |
| Year | 2017 |
| Title | The long noncoding RNA HOTAIR promotes colorectal cancer progression by sponging miR-197 |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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