we found that the levels of HOTAIR and CCAT1 were significantly higher in plasma of CRC patients than that of the healthy control. Moreover, the levels of lincRNA-p21 were obviously decreased in plasma of CRC patients as compared to those of healthy control. There was highly correlated for CCAT1, HOTAIR and lincRNA-p21 in plasma and serum. By receiver operating characteristic curve analysis, plasma CCAT1 provided the higher diagnostic performance for detection of CRC. In conclusion, our results demonstrated that increased plasma HOTAIR and CCAT1 could be used as a predictive biomarker for CRC screening, and that combination of HOTAIR and CCAT1 had a higher positive diagnostic rate of CRC than HOTAIR or CCAT1 alone