Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | Microarray, qRT-PCR, Western blot, Luciferase reporter assay |
| Sample | glioma tissues, glioma cell lines (U87 and U251) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR was aberrantly up-regulated in glioma tissues and was negatively correlated with miR-126-5p expression.Next, we determined that HOTAIR promote glioma progression by sponging miR-126-5p.Subsequently,glutaminase (GLS) was confirmed to be a direct target of miR-126-5p.Moreover,HOTAIR could modulate GLS expression by functioning as a competing endogenous RNA (ceRNA) for miR-126-5p. |
| Pubmed ID | 29319172 |
| Year | 2018 |
| Title | Long non-coding RNA HOTAIR acts as a competing endogenous RNA to promote glioma progression by sponging miR-126-5p. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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