Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | qPCR, RNAi, Luciferase reporter assay, Flow cytometry assay etc. |
| Sample | glioma tissues, cell lines (HA1800, A172) |
| Expression Pattern | up-regulated |
| Function Description | The results confirmed that HOTAIR mRNA expression was inversely correlated with miR-148b-3p expression in A172 glioma cells. The results showed that HOTAIR promotes factors associated with malignancy, including cell proliferation, cell cycle progression and invasion, whereas miR-148b-3p suppresses malignancy. Bioinformatics and luciferase reporter assays showed that miR-148b-3p modulates HOTAIR expression by directly targeting the HOTAIR gene sequence. |
| Pubmed ID | 27446363 |
| Year | 2016 |
| Title | miR-148b-3p inhibits malignant biological behaviors of human glioma cells induced by high HOTAIR expression. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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