Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | gastric cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | we found that HOTAIR was more highly expressed in diffuse-type GC than in intestinal type. In the diffuse type, there is significant relationship between HOTAIR expression and DFS. CDH1 was downregulated in diffuse-type GC tissues and showed a negative relationship with HOTAIR. In addition, HOTAIR knockdown significantly repressed migration, invasion and metastasis both in vitro and vivo and reversed the epithelial-to-mesenchymal transition in GC cells. Moreover, it is demonstrated that HOTAIR crosstalk with microRNAs during epigenetic regulation. |
| Pubmed ID | 26136075 |
| Year | 2015 |
| Title | LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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