Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR etc. |
| Sample | cervical cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR and UCA1 both were significantly higher expressed in GC tumor tissues than adjacent non-tumor tissues. The results from the qRT-PCR validation in 82 newly diagnosed GC patients and the above bioinformatics results were 100% in agreement. HOTAIR and UCA1 were found to be significantly associated with overall survival. The miR-1 was downexpressed when lncRNA UCA1 was overexpressed in glioma cells.mRNA XIRP1 was found to interact with miRNA miR-133a-3p. Key miRNA miR-133a-3p was predicted to target key lncRNA HOTAIR. |
| Pubmed ID | 29620291 |
| Year | 2018 |
| Title | Integrated analysis of long non-coding RNA competing interactions revealed potential biomarkers in cervical cancer: Based on a public database. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for cervical cancer | Omim Cosmic |
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