Compared with the CC genotype, TT genotype was significantly correlated with the elevated expression of HOTAIR; however, the CT genotype did not associate with the HOTAIR upregulation. In addition, we also found that the TT genotype of rs920778 was correlated with advanced tumor stage, highly histological grade, lympho node metastasis and positive infection of high risk HPV. Among the patients who underwent concurrent chemo-radiotherapy, TT genotype carriers present notably resistance to the combination of EBRT + ICBT + cisplatin.