The results showed that HOTAIR expression in cervical cancer tissues was significantly upregulated compared with the matched nontumorous tissues. Increased HOTAIR expression was significantly correlated with FIGO stage, lymph node metastasis, depth of cervical invasion, tumor size and age, but not other clinical characteristics. Moreover, cervical cancer patients with HOTAIR higher expression have shown significantly poorer overall survival and disease-free survival than those with lower HOTAIR expression.