Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, RNAi, Western blot, MTT assay etc. |
| Sample | ovarian cancer tissues, cell lines (A2780, 3AO, OVCAR3, SKOV3, HO-8910) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR overexpression promoted cell cycle progression (and thus cell proliferation) by activating the Wnt/B-Catenin signaling pathway. Likewise, knockdown of HOTAIR suppressed cell proliferation and arrested cell cycle at G1 phase via inhibition of Wnt/B-Catenin signaling. Moreover, the results of primary culture demonstrated that elevated HOTAIR expression correlated positively with chemoresistance in ovarian cancer. |
| Pubmed ID | 26341496 |
| Year | 2015 |
| Title | Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/B-Catenin pathway in human ovarian cancer. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for ovarian cancer | Omim Cosmic |
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