Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, CHIP-PCR, Dual-luciferase reporter assay etc. |
| Sample | cell lines (MDA-MB-231 and MCF-7) |
| Expression Pattern | up-regulated |
| Function Description | To explore why miR-7 expression was downregulated in breast cancer cells and BCSCs, we examined HOTAIR expression and found that the downregulation of miR-7 was closely related to the high level of HOTAIR expression in breast cancer patients. HOTAIR inhibits many tumor suppression genes including HoxD10 in MDA-MB-231 cells. We downregulated the expression of HOTAIR by RNA interference in MDA-MB-231 cells and found that the expression of HoxD10 along with miR-7 were enhanced. |
| Pubmed ID | 25070049 |
| Year | 2014 |
| Title | MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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