Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RC-PCR, Western blot, Luciferase reporter assay |
| Sample | breast cancer cell lines (MDA-MB-231 and MCF-7) |
| Expression Pattern | up-regulated |
| Function Description | Paracrine TGF-B1 was essential for CAFs induced EMT and metastasis in breast cancer cells, which is a crucial mediator of the interaction between stromal and cancer cells. CAF-CM significantly enhanced the HOTAIR expression to promote EMT, whereas treatment with small-molecule inhibitors of TGF-B1 attenuated the activation of HOTAIR. Most importantly, SMAD2/3/4 directly bound the promoter site of HOTAIR, located between nucleotides -386 and -398, -440 and -452, suggesting that HOTAIR was a directly transcriptional target of SMAD2/3/4. Additionally, CAFs mediated EMT by targeting CDK5 signaling through H3K27 tri-methylation. |
| Pubmed ID | 29325547 |
| Year | 2018 |
| Title | Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-1 secretion. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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