Detail
LncRNA Name | HOTAIR |
Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
Region | GRCh38_12:53962308-53974956 Sequence |
Ensembl | ENSG00000228630 |
RefSeq | NR_003716 |
Circulating | ✘ |
Drug-resisitant | ✘ |
Prognostic | ✘ |
MiRNA | ✘ |
Variant | ✘ |
TF | ✘ |
Methylation | ✘ |
Cancer Name | breast cancer |
ICD-0-3 | C50 |
Methods | qPCR, Western blot |
Sample | cell line (MCF-7) |
Expression Pattern | differential expression |
Function Description | We discovered that knockdown of HOTAIR induced significant decrease in proliferation and increase in apoptosis of MCF-7 cells, and the cell cycles of HOTAIR siRNA transfected cells have been arrested at G1 phase (p < 0.01); |
Pubmed ID | 28407576 |
Year | 2017 |
Title | HOTAIR may regulate proliferation, apoptosis, migration and invasion of MCF-7 cells through regulating the P53/Akt/JNK signaling pathway |
External Links |
Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
Links for breast cancer | Omim Cosmic |
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