Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR |
| Sample | gastric cancer tissues, cell lines (BGC-823 and MKN-45) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA HOTAIR had an extremely high expression level in GC cells, and predicted poor prognosis in patients.Down-regulation of HOTAIR could promote chemosensitivity, induce apoptosis of GC cells, and significantly inhibit GC cell proliferation, invasion and metastasis in vivo and in vitro. |
| Pubmed ID | 29236333 |
| Year | 2017 |
| Title | Effect and mechanism of lncRNA HOTAIR on occurrence and development of gastric cancer. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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