Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | cervical cancer tissues, cell lines (SiHa, HeLa, Caski, c4-1 and HaCaT) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR expression was elevated while miR-143-3p expression was reduced in cervical cancer tissues and cell lines.HOTAIR knockdown suppressed proliferation and enhanced apoptosis in cervical cancer cells.Moreover, HOTAIR could function as a sponge for miR-143-3p.The inhibitory effect of HOTAIR knockdown on cervical cancer cells growth was abolished following decrease of miR-143-3p expression.Furthermore, HOTAIR promoted BCL2 expression by modulating miR-143-3p.BCL2 overexpression attenuated the tumor-suppressive effect of miR-143-3p in cervical cancer.Finally, the carcinogenicity of HOTAIR was validated in mice.HOTAIR acted as a ceRNA to modulate BCL2 expression via competitively binding to miR-143-3p. |
| Pubmed ID | 29336659 |
| Year | 2018 |
| Title | Long non-coding RNA HOTAIR promotes cervical cancer progression through regulating BCL2 via targeting miR-143-3p. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for cervical cancer | Omim Cosmic |
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