Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | Tumor tissues, cervical cancer cell lines (SiHa, HeLa, Caski, and C4-1) |
| Expression Pattern | up-regulated |
| Function Description | the expressions of HOTAIR and miR-23b were detected by real-time PCR in 33 paired cervical cancer tissue samples and cervical cell lines. The effects of HOTAIR on the expressions of miR-23b and mitogen-activated protein kinase 1 (MAPK1) were studied by overexpression and RNAi approaches.HOTAIR expression was significantly increased in cervical cancer cells and tissues.In contrast,the expression of miR-23b was obviously decreased.HOTAIR knockdown promoted apoptosis and inhibited cell proliferation and invasion in vitro and in vivo Moreover, our data indicated that HOTAIR may competitively bind miR-23b and modulate the expression of MAPK1 indirectly in cervical cancer cells. |
| Pubmed ID | 29335299 |
| Year | 2018 |
| Title | HOTAIR contributes to cell proliferation and metastasis of cervical cancer via targetting miR-23b/MAPK1 axis. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for cervical cancer | Omim Cosmic |
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