Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name HOTAIR
   Synonyms HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072
   Region GRCh38_12:53962308-53974956    Sequence
   Ensembl ENSG00000228630
   RefSeq NR_003716
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name cervical cancer
   ICD-0-3 C53  
   Methods qPCR, Western blot etc.
   Sample cervical cancer tissues, cell lines (HeLa, SiHa, C33A, CaSki)
   Expression Pattern differential expression
   Function Description

Stable knockdown of HOTAIR significantly suppressed tumor growth and sensitized cervical cancer to radiotherapy in vivo.

   Pubmed ID 25547435
   Year 2014
   Title HOTAIR enhanced aggressive biological behaviors and induced radio-resistance via inhibiting p21 in cervical cancer.
   External Links
   Links for  HOTAIR GenBank       HGNC       lncrnadb       Noncode
   Links for  cervical cancer Omim       Cosmic

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