Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | breast cancer tissues, cell lines (MCF-7 and T47D) |
| Expression Pattern | up-regulated |
| Function Description | HOTAIR was able to up-regulate the expression of Bcl-w in breast cancer cells. miR-206 was capable of inhibiting the expression of Bcl-w by directly binding to the 3'UTR of Bcl-w mRNA.HOTAIR could increase the expression of Bcl-w through sequestering miR-206 at post-transcriptional level. HOTAIR-induced Bcl-w by miR-206 facilitated the proliferation of breast cancer cells.HOTAIR expression in primary breast tumors was significantly associated with worse prognosis independent of prognostic markers. |
| Pubmed ID | 29222472 |
| Year | 2017 |
| Title | Long Noncoding RNA HOTAIR Modulates MiR-206-mediated Bcl-w Signaling to Facilitate Cell Proliferation in Breast Cancer. |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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