Detail
| LncRNA Name | HOTAIR |
| Synonyms | HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Region | GRCh38_12:53962308-53974956 Sequence |
| Ensembl | ENSG00000228630 |
| RefSeq | NR_003716 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR, Western blot etc. |
| Sample | non small cell lung cancer tissues, cell lines |
| Expression Pattern | up-regulated |
| Function Description | The mRNA level of lncRNA-HOTAIR in cancer tissues was significantly higher than that in cancer-adjacent tissues (P<0.05), and the high expression of lncRNA-HOTAIR indicated that the OS of patients was shortened (P<0.05). The IC50 of NCI-H1299/DDP cells inhibiting DDP was 127.82 uM, which was significantly higher than that of parental NCI-H1299 cells (IC50=8.40 uM) (P<0.05). |
| Pubmed ID | 29805510 |
| Year | 2018 |
| Title | The action mechanism of lncRNA-HOTAIR on the drug resistance of non-small cell lung cancer by regulating Wnt signaling pathway |
| External Links |
| Links for HOTAIR | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
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