Detail
| LncRNA Name | HOTAIRM1 |
| Synonyms | HOTAIRM1, HOXA-AS1, HOXA1-AS1, NCRNA00179 |
| Region | GRCh38_7:27095647-27100265 Sequence |
| Ensembl | ENSG00000233429 |
| RefSeq | NR_038366 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | M9861/3 |
| Methods | qPCR etc. |
| Sample | bone marrow |
| Expression Pattern | up-regulated |
| Function Description | Interestingly, HOTAIRM1 was overexpressed in NPM1-mutated AML (P < 0.001) and within this group retained its prognostic value (OR: 2.21; P = 0.01). Moreover, HOTAIRM1 expression was associated with a specific 33- microRNA signature that included miR-196b (P < 0.001). miR-196b is located in the HOX genomic region and has previously been reported to have an independent prognostic value in AML. |
| Pubmed ID | 26436590 |
| Year | 2016 |
| Title | The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature. |
| External Links |
| Links for HOTAIRM1 | GenBank HGNC lncrnadb Noncode |
| Links for acute myeloid leukemia | Omim Cosmic |
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