Detail
| LncRNA Name | HOTTIP |
| Synonyms | HOTTIP, HOXA-AS6, HOXA13-AS1, NCRNA00213 |
| Region | GRCh38_7:27198575-27207259 Sequence |
| Ensembl | ENSG00000243766 |
| RefSeq | NR_037843 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | malignant glioma |
| ICD-0-3 | M9380/3 |
| Methods | qPCR, luciferase reporter assay etc. |
| Sample | glioma tissues, cell lines (U87, U251) |
| Expression Pattern | up-regulated |
| Function Description | HOTTIP was the most upregulated lncRNA in glioma cells treated by hypoxia. High levels of HOTTIP and HIF-1a were correlated with glioma metastasis and poor patient prognosis. Knockdown of HIF-1a and HOTTIP blocked hypoxia-induced EMT, and suppressed invasion and migration of glioma cells. Finally, HOTTIP sponged endogenous miR-101 and inhibited its activity, which resulted in increased ZEB1 expression and promoted process of EMT. HIF-1a/HOTTIP/miR-101/ZEB1 axis plays essential role in hypoxia-induced EMT and metastasis of glioma, and HOTTIP may serve as a therapeutic target to reverse EMT and prevent glioma progression. |
| Pubmed ID | 28886531 |
| Year | 2017 |
| Title | Long non-coding RNA HOTTIP promotes hypoxia-induced epithelialmesenchymal transition of malignant glioma by regulating the miR-101/ZEB1 axis |
| External Links |
| Links for HOTTIP | GenBank HGNC lncrnadb Noncode |
| Links for malignant glioma | Omim Cosmic |
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