Detail
| LncRNA Name | HOTTIP |
| Synonyms | HOTTIP, HOXA-AS6, HOXA13-AS1, NCRNA00213 |
| Region | GRCh38_7:27198575-27207259 Sequence |
| Ensembl | ENSG00000243766 |
| RefSeq | NR_037843 |
| Circulating | ✔ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | cell line (CS12) |
| Expression Pattern | differential expression |
| Function Description | Concurrent regulation of HoxA13-HOTTIP was mediated by the mixed lineage leukemia-WD repeat domain 5 complex, which caused the trimethylation of H3K4 and then stimulated cell proliferation. HoxA13 transactivated the IGFBP-3 promoter through the HOX-binding site. Activation of IGFBP-3 stimulated the oncogenic potential and invasion activity. Increased expression of HoxA13 (63.2%) and IGFBP-3 (28.6%) was detected in human gastric cancer tissues and was found in the gastric cancer data of The Cancer Genome Atlas |
| Pubmed ID | 27144338 |
| Year | 2016 |
| Title | Oncogenic function of the homeobox A13-long noncoding RNA HOTTIP-insulin growth factor-binding protein 3 axis in human gastric cancer |
| External Links |
| Links for HOTTIP | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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