Detail
| LncRNA Name | HOTTIP |
| Synonyms | HOTTIP, HOXA-AS6, HOXA13-AS1, NCRNA00213 |
| Region | GRCh38_7:27198575-27207259 Sequence |
| Ensembl | ENSG00000243766 |
| RefSeq | NR_037843 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | esophageal squamous cell cancer |
| ICD-0-3 | |
| Methods | Western blot, RIP, ChIP, qPCR etc. |
| Sample | ESCC tissues, cell lines (Eca-109, KYSE-30, KYSE-150,KYSE-180, KYSE-410, KYSE-450, KYSE-510, TE-10 and TE-13) |
| Expression Pattern | up-regulated |
| Function Description | HOTTIP modulated HOXA13 at both the transcriptional and posttranscriptional levels in ESCC cells and HOTTIP-miR-30b-HOXA13 axis may serve as potential diagnostic markers or drug targets for ESCC therapies. |
| Pubmed ID | 28534516 |
| Year | 2017 |
| Title | Transcriptional and posttranscriptional regulation of HOXA13 by lncRNA HOTTIP facilitates tumorigenesis and metastasis in esophageal squamous carcinoma cells |
| External Links |
| Links for HOTTIP | GenBank HGNC lncrnadb Noncode |
| Links for esophageal squamous cell cancer | Omim Cosmic |
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