Detail
| LncRNA Name | HOTTIP |
| Synonyms | HOTTIP, HOXA-AS6, HOXA13-AS1, NCRNA00213 |
| Region | GRCh38_7:27198575-27207259 Sequence |
| Ensembl | ENSG00000243766 |
| RefSeq | NR_037843 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | OS tissues, cell lines (SaOS2, MG63 and U2OS) |
| Expression Pattern | up-regulated |
| Function Description | We found that HOTTIP was increased in OS and up-regulated expression of HOTTIP could promoted OS cell proliferation and cell cycle progression by activating the Wnt/B-catenin pathway. Down-regulated expression of HOTTIP inhibited cell proliferation and arrested cell cycle at G1 phase by inhibition of Wnt/B-catenin pathway. Furthermore, our data showed that increased expression of HOTTIP was correlated with chemoresistance in OS. In vitro, HOTTIP induced cellular resistance to cisplatin by activating the Wnt/B-catenin pathway, which could be reversed by treatment with the Wnt/B-catenin inhibitor. |
| Pubmed ID | 27347346 |
| Year | 2016 |
| Title | Overexpression of long non-coding RNA HOTTIP increases chemoresistance of osteosarcoma cell by activating the Wnt/B-catenin pathway. |
| External Links |
| Links for HOTTIP | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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