Detail
| LncRNA Name | AK126698 |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay etc. |
| Sample | NSCLC tissues, cell lines (A549, NCI-H520, and H1299) |
| Expression Pattern | down-regulated |
| Function Description | Our results showed that lncRNA AK126698 was significantly downregulated in NSCLC tissues, compared with paired adjacent nontumor tissue samples. Furthermore, lower AK126698 expression was associated with larger tumor size and advanced tumor stage. Ectopic AK126698 expression inhibited cell proliferation and migration and induced apoptosis. Conversely, decreased AK126698 expression promoted cell proliferation and migration and inhibited cell apoptosis. Importantly, we demonstrated that Frizzled-8, a receptor of Wnt/B-catenin pathway, was a target of AK126698. Furthermore, AK126698 could inhibit the activation of Wnt/B-catenin pathway, which was demonstrated by measuring the expression levels of Axin1, B-catenin, c-myc, cyclin D1, and E-cadherin. |
| Pubmed ID | 27445486 |
| Year | 2016 |
| Title | Long noncoding RNA AK126698 inhibits proliferation and migration of non-small cell lung cancer cells by targeting Frizzled-8 and suppressing Wnt/B-catenin signaling pathway. |
| External Links |
| Links for AK126698 | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
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